Engineered bio-adhesive polyhedral oligomeric silsesquioxane hybrid nanoformulation of amphotericin B for prolonged therapy of fungal keratitis

• BPEP could effectively internalize poorly lipid soluble AMB. possess good bio-adhesiveness, and improves ocular delivery of significantly prolonged drugs retention time on the surface. BPEP-AMB inhibited fungal keratitis with a better efficiency than currently available drugs. Even though is severe corneal disease that can lead to permanent vision loss, its therapeutic management still problematic. This limitation in part attributable fact tear film renewal curtails exposure drug containing eye drops Accordingly, anti-microbial therapy needs be performed repeatedly. Efforts resolve this hindrance include developing formulations prolong surface which turn improve efficacy as well reduce administration frequency. To extend residence surface, we designed novel organic-inorganic hybrid consisting PEG-PPG copolymer modified polyhedral oligomeric silsesquioxane (POSS) groups. Its tailored POSS-micelles both biocompatibility We describe here use mouse model determine effects formulation encapsulating amphotericin B (AMB) condition. The results show AMB leading improved resolution disease. Moreover, treatment strategy had no toxic during either vitro or vivo. Therefore, POSS bearing has potential managing keratitis.